Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain
Identifieur interne : 000332 ( Main/Exploration ); précédent : 000331; suivant : 000333Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain
Auteurs : Azucena I. Carballo-Villalobos [Mexique] ; María-Eva González-Trujano [Mexique] ; Francisco Pellicer [Mexique] ; Francisco J. L Pez-Mu Oz [Mexique]Source :
- BioMed Research International [ 2314-6133 ] ; 2016.
Abstract
Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system. In this study, we investigated the hesperidin antihyperalgesic effects alone or combined with diosmin in a model of neuropathic pain to corroborate a possible synergistic antinociceptive activity. Mechanical and thermal hyperalgesia were assessed in the aesthesiometer and plantar tests, respectively, after chronic constriction injury (CCI) model in rats receiving hesperidin (HS, 5 doses from 10 to 1000 mg/kg) alone or combined with diosmin (DS, 10 and 100 mg/kg) in comparison to gabapentin (31.6 mg/kg). UHPLC-MS analysis of cerebral samples was used to recognize the central concentrations of these flavonoids. Participation of different receptors was also investigated in the presence of haloperidol, bicuculline, and naloxone antagonists. Acute hesperidin administration significantly decreased mechanical and thermal hyperalgesia in CCI rats. Antihyperalgesic response of hesperidin, improved by a combination with diosmin (DS10/HS100) in both stimuli, was blockaded by haloperidol, bicuculline, and naloxone, but not WAY100635, antagonists. Both flavonoids were detected in brain samples. In conclusion, hesperidin alone and combined with diosmin produces antihyperalgesic response in the CCI model in rats. Antihyperalgesic effect of DS10/HS100 combination involves central activity partially modulated by D2, GABAA, and opioids, but not by 5-HT1A, receptors.
Url:
DOI: 10.1155/2016/8263463
PubMed: 27672659
PubMed Central: 5031820
Affiliations:
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Carballo-Villalobos</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio No. 7 “Dolor y Analgesia” del Departamento de Farmacobiología, Cinvestav-Sede Sur, Calz. de los Tenorios No. 235, Col. Granjas Coapa, CP 14330, México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio No. 7 “Dolor y Analgesia” del Departamento de Farmacobiología, Cinvestav-Sede Sur, Calz. de los Tenorios No. 235, Col. Granjas Coapa, CP 14330, México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Trujano, Maria Eva" sort="Gonzalez Trujano, Maria Eva" uniqKey="Gonzalez Trujano M" first="María-Eva" last="González-Trujano">María-Eva González-Trujano</name><affiliation wicri:level="1"><nlm:aff id="I2">Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Pellicer, Francisco" sort="Pellicer, Francisco" uniqKey="Pellicer F" first="Francisco" last="Pellicer">Francisco Pellicer</name><affiliation wicri:level="1"><nlm:aff id="I2">Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio de Neurofarmacología de Productos Naturales de la Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco No. 101, Col. San Lorenzo Huipulco 14370, México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="L Pez Mu Oz, Francisco J" sort="L Pez Mu Oz, Francisco J" uniqKey="L Pez Mu Oz F" first="Francisco J." last="L Pez-Mu Oz">Francisco J. L Pez-Mu Oz</name><affiliation wicri:level="1"><nlm:aff id="I1">Laboratorio No. 7 “Dolor y Analgesia” del Departamento de Farmacobiología, Cinvestav-Sede Sur, Calz. de los Tenorios No. 235, Col. Granjas Coapa, CP 14330, México, DF, Mexico</nlm:aff><country xml:lang="fr">Mexique</country><wicri:regionArea>Laboratorio No. 7 “Dolor y Analgesia” del Departamento de Farmacobiología, Cinvestav-Sede Sur, Calz. de los Tenorios No. 235, Col. Granjas Coapa, CP 14330, México, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Neuropathic pain is caused by a primary lesion, dysfunction, or transitory perturbation in the peripheral or central nervous system. In this study, we investigated the hesperidin antihyperalgesic effects alone or combined with diosmin in a model of neuropathic pain to corroborate a possible synergistic antinociceptive activity. Mechanical and thermal hyperalgesia were assessed in the aesthesiometer and plantar tests, respectively, after chronic constriction injury (CCI) model in rats receiving hesperidin (HS, 5 doses from 10 to 1000 mg/kg) alone or combined with diosmin (DS, 10 and 100 mg/kg) in comparison to gabapentin (31.6 mg/kg). UHPLC-MS analysis of cerebral samples was used to recognize the central concentrations of these flavonoids. Participation of different receptors was also investigated in the presence of haloperidol, bicuculline, and naloxone antagonists. Acute hesperidin administration significantly decreased mechanical and thermal hyperalgesia in CCI rats. Antihyperalgesic response of hesperidin, improved by a combination with diosmin (DS10/HS100) in both stimuli, was blockaded by haloperidol, bicuculline, and naloxone, but not WAY100635, antagonists. Both flavonoids were detected in brain samples. In conclusion, hesperidin alone and combined with diosmin produces antihyperalgesic response in the CCI model in rats. Antihyperalgesic effect of DS10/HS100 combination involves central activity partially modulated by D<sub>2</sub>, GABA<sub>A</sub>, and opioids, but not by 5-HT<sub>1A</sub>, receptors. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bouhassira, D" uniqKey="Bouhassira D">D. Bouhassira</name></author><author><name sortKey="Lanteri Minet, M" uniqKey="Lanteri Minet M">M. Lantéri-Minet</name></author><author><name sortKey="Attal, N" uniqKey="Attal N">N. Attal</name></author><author><name sortKey="Laurent, B" uniqKey="Laurent B">B. 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Takeshima</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Carballo Villalobos, Azucena I" sort="Carballo Villalobos, Azucena I" uniqKey="Carballo Villalobos A" first="Azucena I." last="Carballo-Villalobos">Azucena I. Carballo-Villalobos</name></noRegion><name sortKey="Carballo Villalobos, Azucena I" sort="Carballo Villalobos, Azucena I" uniqKey="Carballo Villalobos A" first="Azucena I." last="Carballo-Villalobos">Azucena I. Carballo-Villalobos</name><name sortKey="Gonzalez Trujano, Maria Eva" sort="Gonzalez Trujano, Maria Eva" uniqKey="Gonzalez Trujano M" first="María-Eva" last="González-Trujano">María-Eva González-Trujano</name><name sortKey="L Pez Mu Oz, Francisco J" sort="L Pez Mu Oz, Francisco J" uniqKey="L Pez Mu Oz F" first="Francisco J." last="L Pez-Mu Oz">Francisco J. L Pez-Mu Oz</name><name sortKey="Pellicer, Francisco" sort="Pellicer, Francisco" uniqKey="Pellicer F" first="Francisco" last="Pellicer">Francisco Pellicer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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